Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0326214
PubChem CID
Molecular Formula
C17H18N4O
Molecular Weight
294.358 g/mol
Synonyms/Alias
[CHEMBL4792380; BDBM50553735]
InChI Key
SODIMCQABALFOL-UHFFFAOYSA-N
InChI
InChI=1S/C17H18N4O/c1-22-14-6-4-13(5-7-14)20-17-8-16-15(9-18-17)19-11-21(16)10-12-2-3-12/h4-9,11-12H...
IUPAC Name
1-(cyclopropylmethyl)-N-(4-methoxyphenyl)imidazo[4,5-c]pyridin-6-amine
CAS Number
N/A (Not available)

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

40 43 0 0 0 0 0 0 0 0999 V2000
-7.6481 -0.5655 0.9737 C 0 0 0 0 0 0 0 0 0 0 0 0
-6.6926 0.3643 0.4739 O 0 0 0 0 0 0 0 0 0 0 0 0
-5.3295 0.082...

Experimental Data

Activity Data

Target Ion Channel
Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2
Uniprot Accession Number
Function
Allosteric Modulator
Species
Rattus norvegicus (Rat)
IC50
N/A (Not available)
EC50
N/A (Not available)
Ki
Ki: 459 nM
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
Not mention
Holding Potential
Not specified
Temperature
Not mention
Test Method
Binding assay ([3H] Ro15-1788)
Test Species
Not specified

Binding Information

Binding Site
Extracellular domain
Binding Site Residue
Benzodiazepine binding site

Disease Information

Related Disease
treatment of cognitive disorders

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
22
Rotatable Bonds
5
logP
3.5935
Complexity
86.5287
TPSA (Ų)
51.97
H-Bond Donors
1
H-Bond Acceptors
5
Ring Count
4
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